Accession Number:

ADA534096

Title:

Biomarkers of Fatigue: Ranking Mental Fatigue Susceptibility

Descriptive Note:

Interim rept. Jan-Sep 2010

Corporate Author:

AIR FORCE RESEARCH LAB BROOKS AFB TX HUMAN EFFECTIVENESS DIRECTORATE

Report Date:

2010-12-10

Pagination or Media Count:

40.0

Abstract:

This is the mental fatigue susceptibility ranking portion of a study seeking to determine metabolic biomarkers for resistance to fatigue. A total of 23 paid subjects completed a fatigue protocol involving informed consent, medical screening, Tuesday and Wednesday evening training on cognitive tasks, providing five urine samples beginning with a Friday morning baseline, refresher training, and an experimental session with six, four hour long blocks starting Friday evening. Subjects showed the expected declines in performance during the 36-hour, 15-minute period of sleep deprivation without caffeine. The simple change from baseline results on the Psychomotor Vigilance Task PVT is recommended as the primary classifier for mental fatigue susceptibility. The next part of the study will use nuclear magnetic resonance NMR spectroscopy, liquid chromatography LC, and mass spectrometry MS of the urine samples to determine if biomarkers are indicators of mental fatigue susceptibility.

Subject Categories:

  • Psychology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE