Novel Method of Noninvasive Detection and Assessment of Gas Emboli and DCS
Final rept. 1 Jun 2007-31 May 2010
HOUSTON UNIV TX
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The goal of this proposal was to develop novel Phase-Sensitive Swept Source Optical Coherence Tomography PhS-SSOCT technique capable of real-time, sensitive, accurate, and noninvasive imaging, monitoring, and quantification of microbubbles in tissues. During these studies, a novel phase resolved system based on SSOCT has been developed. The system has an axial resolution of 10 micrometers phase sensitivity of 0.03 radians, imaging depth of up to 6 mm in air, and in-depth scanning speed of 20 kHz for a single A-line. The performance of the sensing system was carefully evaluated in optical phantoms containing gas microbubbles with different diameter and tissues in vivo. Obtained results demonstrate that bubbles with diameter greater than 10 micrometers could be detected by both structural imaging and phase response whereas bubbles with diameters less than 10 micrometers could be detected by the phase response of the SSOCT with high sensitivity.
- Anatomy and Physiology