Accession Number:

ADA533786

Title:

Bone Mass Gained in Response to External Loading is Preserved for Several Weeks Following Cessation of Loading in 10 Week C57BL/6J Mice

Descriptive Note:

Journal article

Corporate Author:

JERRY L PETTIS MEMORIAL VETERANS MEDICAL CENTER LOMA LINDA CA

Personal Author(s):

Report Date:

2010-01-01

Pagination or Media Count:

8.0

Abstract:

Dynamic loads lead to increases in bone mass. How long these gains are maintained after cessation of loading, however is not fully understood. A long term study was performed in which skeletal changes were monitored by pQCT every 2-4 weeks wks for a 12 wk period after application of external loading using four-point bending device on 10 wk old female C57BL6J mice. 2 wks of loading caused 15-40 increase in bone parameters vBMD, cross sectional area CSA and bone strength yield load, maximum load and toughness. Positive correlations between these two parameters r 0.72 to 0.88 p0.05 suggest that the changes in bone parameters induced by loading are responsible, in part, for the increase in bone strength. Once loading is terminated the bone response did not continue. The vBMD gained by loading was significant for a period of 5 wks and returned to the levels of controls at 12 wks. The CSA though declined but was still significantly elevated at 12 wks. Bone strength showed no difference between loaded and non-loaded bones at 12 wks. Our results show that external loading increased bone mass, was maintained for several weeks after termination of last loading.

Subject Categories:

  • Anatomy and Physiology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE