Platelet Glycoprotein Ib-IX and Malignancy
Annual rept. 1 Sep 2008-31 Aug 2009
ARKANSAS UNIV FOR MEDICAL SCIENCES LITTLE ROCK
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This report describes studies during the previous 12 months that document the use of mouse models of platelet dysfunction in the progression of cancer to metastatic disease. During the next year we propose to examine the relevance of platelet receptors in models of spontaneous metastasis. A transgenic C57BL6J mouse colony expressing MMTV-PyV middle antigen in mammary epithelium has been developed. Mammary gland tumor and lung metastases develop in these mice spontaneously so they will be used in spontaneous metastasis experiments. Breeding with congenic colonies with defective platelet GP receptors will determine the relevance of platelet adhesion and activation to spontaneous tumor metastasis. The importance of metastasis in the prognosis for recovery from breast cancer cannot be under emphasized. Indeed, the spread of metastatic disease represents a fundamental change in significantly shortening the life span of patients with breast cancer. Thus, understanding the molecules that regulate metastasis identifies potential targets for therapeutic intervention that could significantly improve the prognosis for the breast cancer patient. Although the proposed studies are basic in their approach,the ability to target platelet receptors in anti-thrombotic therapy inhibitor of blood clotting is an ongoing avenue for product development within several large pharmaceutical companies.
- Medicine and Medical Research