Defining Genomic Changes in Triple Negative Breast Cancer in Women of African Descent
Annual rept. 1 Jun 2009-31 May 2010
MIAMI UNIV FL
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Breast cancer BC is the second leading cause of cancer death among African-American AA women, with a 20 greater death rate than in Caucasians Cauc. However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of novel genes contributing to AA BC risk. Tumor and normal breast tissue samples from Cauc and AA patients were obtained from the UM Sylvester Breast Tissue Bank UMS BTB. Our main goal was to identify which genes were turned on expressed and which genes were turned off using gene chip technology between tumor and normal samples that were both common and unique among ethnic groups. Based on analysis of 22,000 genes, some common changes in breast cancer were identified, as well as ethnic specific gene expression patterns that may provide important new insights into ethnic differences in clinical outcomes. In this study, we proposed to extend these preliminary findings to a much larger native African tumor bank available via collaboration between Drs. Peter A. Bird a missionary surgeon in Kijabe, Kenya and Mark Pegram UM Sylvester. Additionally, we propose to analyze structural chromosomal alterations associated with gene expression differences utilizing advanced genomic techniques in collaboration with Alan Ashworth, England.
- Medicine and Medical Research