Accession Number:

ADA533255

Title:

Regulation and Action of SKP2 in Cell and Tumor Models: Mechanisms Underlying Aggressive Growth in Basel-Like Breast Cancer

Descriptive Note:

Annual summary rept. 15 May 2009-15 May 2010

Corporate Author:

MASSACHUSETTS UNIV AMHERST

Personal Author(s):

Report Date:

2010-06-01

Pagination or Media Count:

6.0

Abstract:

The objective of this research is to further our understanding of the molecular mechanisms underlying the aggressive growth of estrogen receptor ER-negative, basal-like breast tumors. My goal is to determine if SKP2 is a viable new therapeutic target to specifically treat patients who have tumors that are independent of ER signaling. The most significant result was the establishment of a TMX2-28 cell line that has been stably transfected with a SKP2-shRNA construct. This cell line will be instrumental in elucidating the role that SKP2 plays in breast cancer progression.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE