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Influenza-Like Illness Sentinel Surveillance in Peru

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Acute respiratory illnesses and influenza-like illnesses ILI are a significant source of morbidity and mortality worldwide. Despite the public health importance, little is known about the etiology of these acute respiratory illnesses in many regions of South America. In 2006, the Peruvian Ministry of Health MoH and the US Naval Medical Research Center Detachment NMRCD initiated a collaboration to characterize the viral agents associated with ILI and to describe the clinical and epidemiological presentation of the affected population. MethodologyPrincipal Findings Patients with ILI fever 38uC and cough or sore throat were evaluated in clinics and hospitals in 13 Peruvian cities representative of the four main regions of the country. Nasal and oropharyngeal swabs, as well as epidemiological and demographic data, were collected from each patient. During the two years of this study June 2006 through May 2008, a total of 6,835 patients, with a median age of 13 years, were recruited from 31 clinics and hospitals 6,308 were enrolled by regular passive surveillance and 527 were enrolled as part of outbreak investigations. At least one respiratory virus was isolated from the specimens of 2,688 42.6 patients, with etiologies varying by age and geographical region. Overall the most common viral agents isolated were influenza A virus 25.1, influenza B virus 9.7 parainfluenza viruses 1, 2, and 3, HPIV-1,-2,-3 3.2, herpes simplex virus HSV 2.6, and adenoviruses 1.8. Genetic analyses of influenza virus isolates demonstrated that three lineages of influenza A H1N1, one lineage of influenza A H3N2 and two lineages of influenza B were circulating in Peru during the course of this study. Conclusions To our knowledge this is the most comprehensive study to date of the etiologic agents associated with ILI in Peru.

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  • Medicine and Medical Research

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