Comparison of 10 Hemostatic Dressings in a Groin Puncture Model in Swine
NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
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The use of mineral clay or biologic chitosan materials has improved the efficacy of dressings used in the bleeding control of noncompressible areas. A series of novel manufactured products already evaluated in a vascular transection model was further compared in a severe vascular puncture injury model. Methods Ten hemostatic dressings were tested in anesthetized Yorkshire swine hemorrhaged for 45 seconds in a femoral arterial puncture model. Application of these dressings was followed by 5 minutes of compression about 175 mm Hg, and at 15 minutes, 500 mL resuscitation fluid Hextand was infused during a 30-minute period. The animals were monitored for a 3-hour experimental observation period. Primary outcomes were incidence of bleeding after dressing application and animal survival.
- Medicine and Medical Research