Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography
Final rept. 1 Apr 2004-28 Feb 2009
CITY COLL NEW YORK
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The goal of the research project, Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography, was to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared NIR light for imaging and diagnosing tumors in human breast with high resolution and specificity. In order to realize that goal three different approaches were developed. These are Optical Tomography using Independent Component Analysis OPTICA, Round Trip Matrix RTM approach, and Center of Intensity Time Gated Imaging CITGI. OPTICA is the most developed of these approaches. It has been demonstrated that OPTICA can detect, obtain the threedimensional location information and cross-section images of small absorbing, scattering, and fluorescent targets in model media, and tumors in realistic model breast with considerable accuracy. Further accomplishments include development of a forward model for determining the backscattered polarized light intensity distribution, and initial development of a technique to determine scattering coefficient, absorption coefficient, and anisotropy factor g of breast tissue specimens. Besides detection and localization of tumors in breast, these results may have potential applications in optical biopsy, and lumpectomy. The graduate student supported by the project received his Ph. D., adding another scientist to the ongoing fight against breast cancer.
- Medicine and Medical Research