Rapid Formation of Acrylated Microstructures by Microwave-Induced Thermal Crosslinking
BRIGHAM AND WOMENS HOSPITAL HARVARD MEDICAL SCHOOL CAMBRIDGE MA CENTER FOR BIOMEDICAL ENGINEERING
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We present a rapid and highly efficient method to form microstructure of polyethylene glycol PEG-based acrylates by microwave-induced thermal crosslinking. PEG-based polymeric microstructures such as polymer microarrays and microwells were fabricated on 3-trimethoxysilylpropyl methacrylate TMSPMA-coated glass slides that were placed on top of a silicon wafer. In comparison to ultraviolet UV irradiation curing, microwave-induced thermal crosslinking could be completed within 10s without thermal degradation or oxygen inhibition in the presence of ambient oxygen. Furthermore, the activation of surviving free radical impurities by microwave-induced heating enabled crosslinking even without an exogenous radical initiator. This approach can be beneficial for fabricating various PEG-based microstructures for high-throughput screening assays, cellbased biosensors, and biomedical microdevices.
- Organic Chemistry
- Radiofrequency Wave Propagation