Studies on Metabolism of 1,4-Dioxane
Toxicology rept. Oct 2007-Mar 2010
ARMY PUBLIC HEALTH COMMAND ABERDEEN PROVING GROUND MD
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1,4-Dioxane was added as a stabilizer to the banned degreasing solvent 1,1,1,-trichloroethane, and still has uses in the manufacture of small arms ammunition. Due to past and current uses, dioxane is of concern to the Army with regard to both pollution prevention and remediation of past use. The US Environmental Protection Agency classifies dioxane as a probable human carcinogen based upon animal studies. One of the most important data gaps with respect to dioxane is its potential mode of action in causing cancer. Past work has identified two potential metabolities of dioxane, but definitive studies on the relationship of these possible metabolites to one another in living systems and their possible relation to carcinogenesis have remained unanswered. This report provides information supporting 2-hydroxyethoxyacetic acid HEAA as being the principal metabolite, and provides the first quantitative data on the chemical equilibrium between HEAA and the other potential metabolite-dioxanone. Suggestions for future research are included.
- Water Pollution and Control