Engineered Protein Polymers
Final rept. 1 Jan 2007-31 May 2010
POLYTECHNIC INST OF NEW YORK BROOKLYN
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We have developed protein block polymers as well as homopolymers comprised cartilage oligomeric matrix protein coiled coil C and elastin E. Three fusion - EC, CE and ECE - have been biosynthesized and characterized for their physicochemical properties in addition to the homopolymers. Depending on the orientation and the number of blocks, we discover that the secondary structure and supramolecular assemblies vary. In general, the block polymers assembled into particles that presented different mechanical properties. The C homopolymer, however, is able to assemble into fibers in a metal dependent fashion. Finally, we demonstrate that we can control the thermoresponsive behavior of the block polymer through the control of the E domain length.
- Medicine and Medical Research
- Polymer Chemistry