Increasing Rates of Obesity Among HIV-Infected Persons During the HIV Epidemic
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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Background The prevalence and factors associated with overweightobesity among human immunodeficiency virus HIV- infected persons are unknown. Methods We evaluated prospective data from a U.S. Military HIV Natural History Study 19852004 consisting of early diagnosed patients. Statistics included multivariate linear regression and longitudinal linear mixed effects models. Results Of 1682 patients, 2 were underweight, 37 were overweight, and 9 were obese at HIV diagnosis. Multivariate predictors of a higher bodymass index BMI at diagnosis included more recent year of HIV diagnosis, older age, African American race, and earlier HIV stage all p,0.05. The majority of patients 62 gained weight during HIV infection. Multivariate factors associated with a greater increase in BMI during HIV infection included more recent year of diagnosis, lower BMI at diagnosis higher CD4 count, lower HIV RNA level, lack of AIDS diagnosis, and longer HIV duration all p,0.05. Nucleoside agents were associated with less weight gain other drug classes had no significant impact on weight change in the HAART era. Conclusions HIV-infected patients are increasingly overweightobese at diagnosis and during HIV infection. Weight gain appears to reflect improved health status and mirror trends in the general population. Weight management programs may be important components of HIV care.
- Medicine and Medical Research