Investigating the Functional Role of Prostate-Specific Membrane Antigen and Its Enzymatic Activity in Prostate Cancer Metastasis
Final rept. Jan 2006-28 Oct 2009
GENERAL HOSPITAL CORP BOSTON MA
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It is fundamentally important to understand the underlying mechanisms regulating prostate caner PCa metastasis. Despite the increased PSMA expression found in more advanced stage of PCa, little is known about the functional role of PSMA in PCa progression. With this founding from the Department of Defense Prostate Cancer Research Program, we have achieved each of these tasks during the course of this project. We have been able to 1 monitor PSMA expression in live PCa cells, 2 examine its function in cell adhesion, 3 establish its role in cell migration, 4 identify fibronetin as a specific extracellular matrix for enhanced PSMA-positive cell attachment, 5 determine the association of PSMA with integrin, a key signaling molecule known to controlling cancer progression and metastasis and 6 characterize its enzymatic activity in regulation of cell attachment and migration. Our work has contributed to new insight into the role of PSMA in PCa progression. Knowledge of PSMA in cell adhesion and migration will have a direct impact on the design of targeted treatment for patients suffering metastatic PCa.
- Anatomy and Physiology
- Medicine and Medical Research