Dietary Influences on Alpha-Methylacyl-CoA Racemase (AMACR) Expression in the Prostate
Annual rept. 1 Apr 2009-30 Mar 2010
CHICAGO UNIV IL
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Alpha Methyl Acyl CoA Racemase AMACR, a peroxisomal and mitochondrial enzyme, is up regulated in majority of prostate cancers PCa. This enzyme is involved in the breakdown of phytanic pristanic acids, which are derived primarily through the ingestion of dairy and red meat products. There are no studies done so far that have examined the relationship of this enzyme with red meat and dairy intake and therefore PCa risk. The current research focuses on examining the relationships between AMACR expression in the prostate and phytanicpristanic acid levels in the blood and prostate. So far, 30 patients with Pca have been recruited in the study at UIC JBVAMC. Research staff has been trained to obtain dietary information and process tissue and blood samples from participants. Protocols for processing biological samples have been established. Optimization of phytanic pristanic acid assays has been completed and assays for quantifying AMACR using automated image analysis tools have been developed. Data and biological samples from 40 additional subjects are expected from a newly established collaboration with the Henry Ford Health System.
- Medicine and Medical Research
- Food, Food Service and Nutrition