Development and Optimization of a Dedicated, Hybrid Dual-Modality SPECT-CmT System for Improved Breast Lesion Diagnosis
Annual summary rept. 1 Jan-31 Dec 2009
DUKE UNIV DURHAM NC OFFICE OF SPONSORED PROGRAMS
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The overall objective of this project was to implement a dual-modality single photon emission computed tomography SPECT and x-ray computed mammotomography CmT system for the detection and staging of breast cancer, monitoring of treatment therapies, and improving surgical biopsy guidance. The sequential acquisition with emission nuclear and transmission x-ray 3D imaging systems can aid in localizing the radioactive uptake of a tumor from the emission image by using the anatomical structure from the transmission image. In this third and final year, CmT scatter correction was implemented to help in characterizing different materials in vivo in the CmT reconstructed images based on absolute attenuation values. Attenuation correction of SPECT images was also initiated. Different attenuation maps were compared by measuring SNR, contrast, and quantification of radiotracer uptake. Other aspects of the training program were accomplished including the publication of two first author manuscripts in a peer-reviewed journal, presentations at various local and international conferences, and writing of the PhD dissertation.
- Medicine and Medical Research
- Medical Facilities, Equipment and Supplies