Contrast Enhancement for Thermal Acoustic Breast Cancer Imaging via Resonant Stimulation
Final rept. 27 Feb 2006-26 Feb 2010
FLORIDA UNIV GAINESVILLE
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This research focuses on developing enhanced contrast thermal acoustic imaging TAI technology for the detection of breast cancer by combining amplitude-modulated AM electromagnetic EM field excitation, resonant acoustic scattering, and advanced signal processing techniques. EM-induced TAI combines the merits of both EM stimulation and ultrasound imaging, while overcoming their respective limitations. While EM-induced TAI possesses great promise, the thermal acoustic signals tend to be weak. However, when the tumor is excited into resonance via EM stimulation, the effective acoustic scattering cross-section may increase by a factor in excess of 100 based on predictions for microsphere-based ultrasound contrast agents. Such an increase would truly be revolutionary, making the EM-induced TAI technology a very promising candidate for routine breast cancer screening. The image formation methods in the existing TAI systems are data-independent and have poor resolution and high sidelobe problems. We devise adaptive image formation algorithms to achieve high resolution and excellent interference and noise suppression capability.
- Medicine and Medical Research