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Cone-Beam Computed Tomography for Image-Guided Radiation Therapy of Prostate Cancer

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Annual summary rept. 11 Dec 2006-11 Dec 2009

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The success of modern radiation therapy such as intensity-modulated radiation therapy IMRT or conformal radiation therapy CRT is heavily reliant on accurate image guidance in prostate cancer treatment. Cone-beam computed tomography CBCT is becoming one of the dominant imaging modalities for image-guidance partly because of its rich image information and its ease of use. However, current technology based on the Feldkamp-Davis-Kress FDK algorithm for image reconstruction from a circular scanning trajectory does have more room to improve in terms of image quality and accuracy. In addition, the imaging radiation dose is one of the key issues. This is of paramount importance especially in repeated scans during the treatment process to adapt treatment plans to changes in prostate over time. The overall objective of this project is to investigate and develop innovative CBCT scanning methods and corresponding image reconstruction algorithms that can increase the accuracy of the images of the patients prostate andor reduce patient dose from CBCT. Reverse helical CBCT has been proposed, and image reconstruction algorithms for the reverse helical scan have been developed and investigated. Region-of-interest imaging methods based on the chord-based reconstruction algorithm have been explored and applied to CBCT. A few-view CBCT approach based on iterative reconstruction algorithms has also been studied.

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  • Medicine and Medical Research
  • Optics

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