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A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk

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Final rept. 1 Nov 2008-31 Oct 2009

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We are completing this project to use a germ cell deficient Wv mouse model to test the hypothesis of a synergy between oncogenic mutations and postmenopausal biology in ovarian cancer development. We found that crossing of Wv mice into mutant p53 or pten - background did not lead to a malignant tumor phenotype Aim 1. Instead, the mutants rescue ovarian germ cells, a very interesting finding. The ovarian surface epithelia in WvWvp27 - or WvWvp27 - compound mutant mice develop unique lesions with peculiar morphology and formed large ovarian tumors in older mice Aim 2. The analysis of tumor phenotypes Aim 3 is ongoing and we hope to complete and report the findings in next several months. Thus, in this project we have successfully developed WvWvp27 - mice as suitable models of ovarian epithelial cancer. We conclude that the result support our hypothesis that the collaboration of reproductive factors and genetic mutations leads to the development of ovarian cancer. The study also provides us with future directions, and we plan to seek future support to use flox-p53 mutant mice to create additional models. In sum, the project is completed as planned and is successful, and provides basis for further advance.

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  • Medicine and Medical Research

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