PSA Prodrug-Based Multimodality Agents for Imaging Metastatic Prostate Cancer
Annual rept. 1 Apr 2009-31 Mar 2010
JOHNS HOPKINS HOSPITAL BALTIMORE MD
Pagination or Media Count:
The purpose of this work is to prepare and test a series of PSA binding prodrugs which contain both a fluorescent and radioactive group which can bind to enzymaticly active PSA in the vicinity of the tumor where the polar peptide portion is cleaved producing a lipophilic cleavage product which intercalates in the cell membrane of the tumor and nearly cells. In this period we made progress in the synthesis of iodinated and radioiodinated fluorescent PSA prodrugs and PSA cleavage products. In particular we were able to introduce the acid labile tributyl tin moiety needed to incorporate the radioiodine into the molecule towards the end of the synthetic route.
- Medicine and Medical Research