Molecular Mechanisms Underlying Individual Differences in Response to Stress in a Previously Validated Animal Model of PTSD
Annual rept. 1 Sep 2008-31 Aug 2009
BRONX VETERANS MEDICAL RESEARCH FOUNDATION INC (VETERANS AFFAIRS) NEW YORK
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Purpose To make use of an existing rat model for PTSD where individual differences in long-term behavioral responses to the scent of a predator results in extreme responses for 25 of animals thought to be analogous to PTSD, while 25 of the animals show stress resistance. That the extreme behavioral effects can be blocked by cortisol administration prior to stress appears similar to observations in trauma survivors of the prophylactic effects of cortisol. The animal model has not been used to identify CNS gene expression patterns or other biomarkers underpinning biological mechanisms of individual differences in reactivity.
- Anatomy and Physiology
- Medicine and Medical Research
- Stress Physiology