Genome Wide Association Study to Identify SNPs and CNPs Associated with Development of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy
Annual rept. 30 Sep 2008-29 Sep 2009
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
Pagination or Media Count:
The hypothesis that forms the basis for this research is that patients who possess certain SNPs or CNPs are at a greater risk for developing severe urinary morbidity or ED resulting from radiotherapy for prostate cancer. The specific aim of this project is to identify through a genome wide association study the SNPs and CNPs associated with the development of severe urinary morbidity and ED resulting from the use of radiation to treat prostate cancer. It should be noted that we may also identify SNPs or CNPs that are associated with protection against the development of these forms of radiation injury. The main accomplishment of the first year of the project was the performance of a rigorous review of the subjects to be genotyped in this study to insure that all criteria were met for their designation as cases and controls. In addition, all technical issues were resolved to enable performance of genome wide genotyping with Affymetrix 6.0 arrays as well as establishment of the assays for SNP and CNP genotyping that will be performed with a replication set of subjects.
- Anatomy and Physiology
- Medicine and Medical Research