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Literature-Related Discovery: Potential Treatments and Preventives for SARS

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Literature-related discovery LRD is the linking of two or more literature concepts that have not been linked previously in the literature i.e., disjoint in order to produce novel, interesting, plausible, and intelligible connections i.e., potential discovery. The open discovery systems ODS component of LRD starts with an unsolved problem, and generates solutions to that problem through potential discovery. ODS LRD has been used to identify potential treatments or preventative actions for challenging medical problems, among myriad other applications. For the present paper, SARS was selected as the first application of LRD to an infectious disease. The first goal of this research was to identify non-drug non-surgical treatments that would 1 prevent the occurrence, or 2 reduce the progression rate, or 3 stopreverse the progression of SARS. The MeSH taxonomy of Medline was used to restrict potential discoveries to selected semantic classes, and to identify potential discoveries efficiently. The second goal was to generate large amounts of potential discovery in more than an order of magnitude less time than required for the authors previous Raynauds Phenomenon LRD study. To enhance the volume of potential discovery, databases were used in addition to Medline. These included the Science Citation Index SCI and a full text database for the first time. Because of the richness of the full text, surgical queries were developed that targeted the exact types of potential discovery of interest while eliminating clutter more efficiently.

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  • Information Science
  • Medicine and Medical Research

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