Accession Number:

ADA525230

Title:

Androgen, Estrogen and the Bone Marrow Microenvironment

Descriptive Note:

Final rept. 29 Nov 2005-28 Nov 2009

Corporate Author:

FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA

Personal Author(s):

Report Date:

2009-12-01

Pagination or Media Count:

21.0

Abstract:

We have accomplished the following 1 Characterized androgen responsive genes in mouse bone marrow BM via castration androgen ablation and estrogen stimulation. 2 Measurements of testosterone, dihydrotestosterone and of genes that regulate the local androgenconcentration in samples of human bone marrow. 3 Generating a human model system for studies of androgen regulation of the bone marrow stroma and its effects on cancer cells. 4 Established a 3D system of bone marrow stromal cells and DU145 cancer cells we report the outcomes that are relevant to each of the tasks listed in the grant We are organizing the animal work for the human bone marrow xenograft studies in mice by generating the appropriate stromal cell lineandrogen response system and determining the most effective controls to address the complexity of the mousehuman heterologous system.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE