Dietary and Environmental Exposure to Cadmium and the Risk of Breast Cancer
Annual rept. 15 Sep 2008-14 Sep 2009
NORTHERN CALIFORNIA CANCER CENTER FREMONT CA
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This proposed study will examine whether exposure to cadmium Cd from dietary or environmental sources increases the risk of breast cancer. We will examine this hypothesis using information collected from the California Teachers Study CTS cohort, a group of approximately 130,000 female school employees living in California followed for breast cancer since 1995. Information collected by questionnaire includes residential addresses, exposure to tobacco smoke, and food and beverage consumption. We will assess levels of dietary and environmental exposure by linking these collected data with available information on Cd residue levels in foods and beverages and environmental sources of Cd pollution near womens residences. In addition, we will estimate total Cd exposure by using existing urine samples provided by 304 women in the CTS to determine the relative contributions of dietary and environmental sources to the level of urinary Cd, which is considered a good measure of cumulative lifetime exposure. We will then evaluate whether dietary, environmental, and total exposure to Cd increase the risk of breast cancer. To date, we have successfully completed the tasks scheduled for completion in the first year, including the acquisition and cleaning of datasets and the measurement of creatinine-adjusted concentrations of Cd in urine specimens collected from women participating in the validation sub-study. The mean concentration and standard deviation were 0.43 and 0.24 ugg creatinine, respectively.
- Medicine and Medical Research
- Food, Food Service and Nutrition