Accession Number:

ADA523982

Title:

Development of Antibodies Against Novel Cell Surface Proteins in Hormone Refractory Prostate Cancer

Descriptive Note:

Annual rept. 1 Jul 2008-30 Jun 2009

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

2009-07-01

Pagination or Media Count:

8.0

Abstract:

N-cadherin is a cell surface marker that is overexpressed in hormone refractory prostate cancer and targeting this protein either diagnostically or therapeutically may have clinical utility. We initially observed that the cadherin profiles of certain prostate cancer cell lines and xenografts correlated with their level of invasiveness. In addition, we saw that amongst certain hormone refractory xenograft models, there was a consistent upregulation of N-cadherin when compared to its androgen dependent counterpart. We generated specific monoclonal antibodies against different domains of N-cadherin in an attempt to determine if blockade could decrease invasion and metastasis. In the first two years of the grant, we characterized these antibodies and determined that they had measurable in vitro activity. For the third year of the grant, there has been an increased focus on the in vivo effects of two specific antibodies that were generated and their mechanism of action.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE