Optical Approaches for Drug Screening Based Light-Harvesting Conjugated Polyelectrolyte
Final rept. Sep 2008-Mar 2010
CALIFORNIA UNIV SANTA BARBARA DEPT OF CHEMISTRY AND BIOCHEMISTRY
Pagination or Media Count:
Multifunctional materials that can simultaneously provide therapeutic action and image the ensuing results provide new strategies for treating various diseases. In response, we have shown that a cationic conjugated polyelectrolyte with a molecular design containing a polythiophene-porphyrin dyad PTP has efficient anticancer and antifungal activities. Due to the light-harvesting ability of the electronically delocalized backbone and efficient energy transfer amongst the optical partners, the PTP shows a higher 102 generation efficiency and therefore improved therapeutic activity than a small molecule analog. Additionally, the fluorescent properties of PTP serve for another purpose, namely distinguishing amongst living and dead cells. PTP is therefore a promising multifunctional photosensitive agent for treating cancers and fungal infections, while concurrently providing optical monitoring capabilities.
- Medicine and Medical Research