Accession Number:

ADA523443

Title:

Optical Approaches for Drug Screening Based Light-Harvesting Conjugated Polyelectrolyte

Descriptive Note:

Final rept. Sep 2008-Mar 2010

Corporate Author:

CALIFORNIA UNIV SANTA BARBARA DEPT OF CHEMISTRY AND BIOCHEMISTRY

Personal Author(s):

Report Date:

2010-03-01

Pagination or Media Count:

32.0

Abstract:

Multifunctional materials that can simultaneously provide therapeutic action and image the ensuing results provide new strategies for treating various diseases. In response, we have shown that a cationic conjugated polyelectrolyte with a molecular design containing a polythiophene-porphyrin dyad PTP has efficient anticancer and antifungal activities. Due to the light-harvesting ability of the electronically delocalized backbone and efficient energy transfer amongst the optical partners, the PTP shows a higher 102 generation efficiency and therefore improved therapeutic activity than a small molecule analog. Additionally, the fluorescent properties of PTP serve for another purpose, namely distinguishing amongst living and dead cells. PTP is therefore a promising multifunctional photosensitive agent for treating cancers and fungal infections, while concurrently providing optical monitoring capabilities.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE