Accession Number:

ADA523423

Title:

Lymph Node Melanosis in a Patient With Metastatic Melanoma of Unknown Primary

Descriptive Note:

Journal article

Corporate Author:

NATIONAL NAVAL MEDICAL CENTER BETHESDA MD

Report Date:

2009-08-01

Pagination or Media Count:

4.0

Abstract:

Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage CD68 and negative for those of melanocytic lineage S100, HMB-45, Melan-A. This process is rarely described in lymph nodes. We present a report of a patient with melanosis involving multiple lymph nodes of an axillary dissection, done for metastatic melanoma with an unknown primary, and discuss possible prognostic and treatment factors.n

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE