Canonical Wnt Signaling as a Specific Marker of Normal and Tumorigenic Mammary Stem Cells
Annual rept. 1 Feb 2009-31 Jan 2010
VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS MI
Pagination or Media Count:
We have determined that the WntB-catenin signaling pathway is active within a small subset of cells within the mammary gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical Wnt signaling may be a very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.
- Medicine and Medical Research