Accession Number:

ADA522048

Title:

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties (POSTPRINT)

Descriptive Note:

Journal article

Corporate Author:

AIR FORCE CIVIL ENGINEERING CENTER TYNDALL AFB FL

Personal Author(s):

• Eby, D. M.
• Farrington, Karen E.
• Johnson, Glenn R.

Report Date:

2008-07-01

Pagination or Media Count:

10.0

Abstract:

Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of self-synthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.

Descriptors:

• *ANTIMICROBIAL AGENTS
• *BIOCIDES
• *PEPTIDE HYDROLASES
• THERAPY
• NANOPARTICLES
• INORGANIC MATERIALS
• PROTEINS
• PEPTIDES
• CATIONS
• ANTIBIOTICS

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE