Accession Number:

ADA518880

Title:

Cerebrovascular Injury in Blast Loading

Descriptive Note:

Annual rept. 15 Dec 2008-14 Dec 2009

Corporate Author:

UTAH UNIV SALT LAKE CITY

Personal Author(s):

• Monson, Kenneth L.

Report Date:

2010-01-01

Pagination or Media Count:

10.0

Abstract:

The central hypothesis of this project is that the function of the cerebral vasculature is impaired in response to primary blast loading. A shock tube is being utilized to study overpressure alteration of cerebral blood flow and disruption of the blood-brain barrier in the living rat, along with change of passive and active response of isolated rat cerebral vessels. Key accomplishments during the first year of this award include construction of a shock tube, development of a computational model to simulate blast production using a shock tube, and modification of a vessel testing system to accommodate rat cerebral vessels and to allow fluid circulation with temperature and pH control.

Descriptors:

• *BRAIN
• *WOUNDS AND INJURIES
• RATS
• OVERPRESSURE
• PASSIVE SYSTEMS
• RESPONSE
• HYPOTHESES
• LIFE(BIOLOGY)
• CIRCULATION
• BLAST
• PH FACTOR
• BLOOD VESSELS
• BLOOD CIRCULATION
• SHOCK TUBES
• CEREBRUM
• CEREBROVASCULAR SYSTEM
• TEST AND EVALUATION
• MATHEMATICAL MODELS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE