Accession Number:

ADA518111

Title:

Development of Complement Inhibitors to Limit Tissue as Adjuvants to Resuscitation

Descriptive Note:

Annual summary 23 Mar 2007-22 Feb 2010

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

Report Date:

2010-03-01

Pagination or Media Count:

102.0

Abstract:

We have produced evidence to urge the development of six new drugsbiologics to use in battlefield injury. We have We have established that DAF limits tissue injury and moved it to large animals of polytrauma injury. We have defined the importance of C5a in tissue injury and we have recommended that C5a inhibitors may be of value in limiting tissue injury. Finally we have introduce a novel inhibitor, CRIg, in the field of tissue injury. We have established that T cells and B cells are important in the execution of injury. We have demonstrated the importance of Annexin IV in instigating tissue injury. A discovery approach has revealed yet novel targets that may limit tissue injury. Our first finding was that actin polymerization is important for the expression of tissue injury. While ourselves are moving some of them to the next phase, we believe that the information that we have published will be of value to the industry and government agencies in carrying on large animal and clinical studies.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE