Discovery of Newer Therapeutic Leads for Prostate Cancer
Annual rept. 1 Jun 2008-14 May 2009
TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
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For many prostate cancer patients currently available drugs do not stop the lethal progression of the disease. There is a critical need for more effective therapies for the treatment of late-stage, metastatic prostate cancer. We will test the hypothesis that new drugs andor drug leads for the treatment for metastatic prostate cancer can be identified from the understudied plants of Texas. In this effort we will prioritize the most promising plant extracts and then prepare large-scale quantities of the plant extracts using supercritical fluid extraction techniques and use this material for bioassay-guided fractionation of the biologically active constituents using modern chromatography techniques. The chemical structures of isolated compounds will be determined using NMR spectroscopy. Detailed biological evaluations will be conducted on compounds isolated.
- Medicine and Medical Research