Accession Number:

ADA517509

Title:

The Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

Descriptive Note:

Annual summary rept. 20 Aug 2006-29 Aug 2009

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

Report Date:

2009-09-01

Pagination or Media Count:

19.0

Abstract:

The goal of my project as outlined in the original application is to analyze the role of Protein Kinase D PKD in breast cancer cell motility, the phenotype critical for metastasis. The work I have conducted includes the demonstration that loss of PKD in a number of highly metastatic breast cancer cell lines results in a migration defect. I have also discovered a potential isoform specificity of PKD in the control of breast cancer cell motility.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE