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ProCEED Pilot Study (Prostate Cancer Study of Ethnicity, Exercise and Diet)

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Annual rept. 30 Nov 2008-29 Nov 2009

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Prostate cancer has a huge and growing burden of disease, yet its natural history has not been fully elucidated. Further, it is unknown why African American men have the highest incidence rates in the world. The overall goals of the ProCEED pilot study are as follows 1 to advance understanding of the IGF axis and its interplay with racegenetics and dietarylifestyle risk factors for prostate cancer, 2 to elucidate modifiable risk factors that interact with genetics and possibly lead to a greater incidence of prostate cancer among African Americans, and 3 to disseminate learned information in an effort to prevent disease. It is hypothesized that racial differences in prostate cancer risk are attributed, in part, to interactions between lifestyle factors and the IGF axis. This study attempts to elucidate dietary and lifestyle risk factors which may operateinteract uniquely in African Americans. If there are lifestyle risk factors for prostate cancer that can be modified, this would be valuable information for primary and perhaps secondary prevention of prostate cancer. The fourth year of the grant was dedicated to the completion of subject enrollment and the beginning of the data analysis phase of the project. At the end of the enrollment period there were 87 subjects enrolled into the study 57 prostate cancer cases and 30 controls. A no-cost extension has been requested to process the lab samples and finish the study in 2010. Data management activities, dietary data analysis, laboratory sample processing, and study data entry are currently underway. No final results from this study are yet available.

Subject Categories:

  • Sociology and Law
  • Medicine and Medical Research
  • Food, Food Service and Nutrition
  • Stress Physiology

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