Accession Number:

ADA517349

Title:

PCBs Alter Dopamine Mediated Function in Aging Workers

Descriptive Note:

Annual rept. 15 Dec 2008-14 Dec 2009

Corporate Author:

HEALTH RESEARCH INC MENANDS NY

Personal Author(s):

Report Date:

2010-01-01

Pagination or Media Count:

39.0

Abstract:

The major hypothesis is that prior occupational exposure to polychlorinated biphenyls PCBs results in decrements in the number of dopamine DA terminals in the basal ganglia determined by Beta-CIT SPECT imaging. Data collection is complete a comprehensive questionnaire, examinations and SPECT imaging. PCBs and thyroid hormones have been measured in serum and bone lead has been determined. Results, obtained using -CIT SPECT imaging, demonstrate a significant negative relationship between current serum PCB concentrations and decreases in the density of -CIT binding only in women. Serum PCB concentrations have decreased 10-fold from peak values during occupational PCB use but remain elevated two-fold compared to a similar-aged non-occupationally exposed population. Estimating PCB half lives using analysis of both current and archived serum samples revealed significantly longer half lives for PCB congeners of occupational origin in women compared to men. Data analysis and manuscript preparation continues for neurological and neuropsychological endpoints.

Subject Categories:

  • Medicine and Medical Research
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE