Accession Number:

ADA517339

Title:

The Influence of Physical Forces on Progenitor Cell Migration, Proliferation and Differentiation in Fracture Repair

Descriptive Note:

Annual rept. 1 Nov 2007-31 Oct 2008

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Report Date:

2008-11-01

Pagination or Media Count:

21.0

Abstract:

The goal of this program is to investigate the influence of controlled mechanical stimulation on the behavior of progenitor cells in an effort to develop strategies to significantly enhance the rate and quality of fracture repair in long bone. Progress in the program has been excellent. The results to date demonstrate the application of load increases the callus volume, bone mineral density and biomechanical properties. More importantly, the data demonstrates a substantial independence on the time of load application. Load stimulation can positively influence fracture repair when applied at 10 or 24 days after fracture, while early application during granulation tissue formation may be detrimental to tissue regeneration. We also demonstrated that introduced progenator cells play an indirect role on the repair and identified a variety of factors that may be associated with repair cell recruitment. The results are beginning to support new strategies for enhancing fracture repair

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE