Accession Number:

ADA517265

Title:

Immune Response Augmentation in Metastasized Breast Cancer by Localized Therapy Utilizing Biocompatible Magnetic Fluids. Addendum

Descriptive Note:

Final addendum rept. 1 Aug 2008-31 Jul 2009

Corporate Author:

NEVADA UNIV RENO NV

Report Date:

2009-08-01

Pagination or Media Count:

22.0

Abstract:

During the second year Magneto-rheological Fluid MRF iron nano-particles were synthesized using the reverse micelle technique and coated with polyNIPAAm. The size distribution of the nano iron particles was characterized using dynamic light scattering DLS. The particle size was 730nm, and the Tg of the coating was characterized using DSC. The 80 wt. MRF based on phosphate buffered saline PBS and iron particles was characterized using the shear rheometer in the range of shear rates from 1Hz - 400Hz at room temperature. Shear stress and shear viscosity of MRF was found to increase with the applied magnetic flux density. According to the Bingham model, the yield stress of MRF can be found by extrapolating the shear stress curve at zero shear rate. The mathematical model developed during the first year was used to explore the dynamics behavior of iron particles injected into tumor and resulting force and stress applied on the neighboring tissue under magnetic field. The effect of particle size on these values is investigated. Results showed that stress on the neighboring tissue is increased linearly with the increasing particle size.

Subject Categories:

  • Medicine and Medical Research
  • Operations Research
  • Fluid Mechanics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE