Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer
Annual rept. 15 Aug 2008-14 Aug 2009
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
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Characterization of major TMPRSS2-ERG splice variants in prostate cancer specimens for the first time provides information on the full length protein coding sequences of TMPRSS2-ERG fusion transcripts which is urgently needed in developing more precise bio-marker and therapeutic strategies. Unexpected discovery on predominance of type II splice variants e.g., TMPRSS2-ERG8 and identification of novel splice variants TMPRSS2-EPC1 and TMPRSS2-EPC2 represents the unique outcome of this grant effort focusing on unbiased evaluation of fusion transcripts in prostate cancer. Definition of the relative abundance of the TMPRSS2-ERG splice variants in prostate cancer provide novel information with respect to type II TMPRSS2-ERG transcripts and prognostic value of measuring the ratio of type II and type I transcripts. These data suggest that over all biologic effects of TMPRSS2-ERG fusion may be a reflection of potential interaction of these splice variants.
- Medicine and Medical Research