Accession Number:

ADA517257

Title:

Targeting siRNA Missiles to Her2+ Breast Cancer

Descriptive Note:

Annual rept. 15 May 2008-14 May 2009

Corporate Author:

CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA

Personal Author(s):

Report Date:

2009-06-01

Pagination or Media Count:

10.0

Abstract:

The most significant findings here are that HerPBK10 protects siRNA from serum nuclease-mediated degradation, T7 transcribed siRNA is more cytotoxic than synthetic siRNA when delivered to HER2 breast cancer cells by HerPBK10 in vitro, HerPBK10 directs siRNA-mediated cytotoxicity to HER2 but not HER2- cells in vitro, the HerPBK10 carrier preferentially accumulates in HER2 tumors in vivo when delivered systemically intravenously, and cytotoxicity is associated with siRNA-mediated induction of IFN-alpha.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE