Biocompatibility and Toxicological Effects of Doped, Functionalized and Pure Carbon Nanotubes
Final rept. 1 Apr 2008-31 May 2009
INSTITUTO POTOSINO DE INVESTIGACION CIENTIFICA Y TECNOLOGICA SAN LUIS POTOSI (MEXICO)
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We wrote a review article for Advanced Materials together with Dr. Hussains group about the toxicity evaluation for safe use of nanomaterials. This paper has been highlighted by the journal as of the of the most downloaded papers in two months see report. From the experimental standpoint, we synthesized different types of carbon nanotubes CNTs multiwalled carbon nanotubes MWNTs, nitrogen-doped CNx MWNTs, phosphorus- and nitrogen-doped CNxPy MWNTs, ethanol -based carobonyl, carboxyl functionalized CNT COx-MWNTs and B-doped CBx MWNTs. We also prepared and evaluated different suspensions for biological applications of CNTs. We found that H2S04, acetic acid, HNO3VH2S04 mixtures and chloroform were suitable for suspending the different types of tubes. Ag nanopartides were chemically anchored on the surface of MWNTs. COxMWNTs and CNxMWNTs. Cellular function and immune response were evaluated to determine biocompatibility of the synthesized nanomaterials on the human keratinocyte cell lineHaCaT. Cellular assays revealed toxicity after 24h. However, full cellular recovery was observed at 48h. Therefore AG nanoparticles if anchored to CNTs have ability to interact with cells and preserve cellular function.