Accession Number:

ADA516650

Title:

Killing Breast Cancer Cells Through Activation of the Apoptosome

Descriptive Note:

Final rept. 8 May 2006-7 May 2009

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

• Kornbluth, Sally

Report Date:

2009-06-01

Pagination or Media Count:

7.0

Abstract:

Cells die in response to chemotherapeutic agents by activating pathway. This pathway leads to activation of proteases known of cytochrome c from mitochodria. Once released, cytochrome known as Apaf-1, which oligomerizes and activates caspase cancer cells have apoptosomes which are hypersensitive to develop cytoplasmic variants of cytochrome c andor small to activate the apoptosome in breast cancer cells.

Descriptors:

• *MITOCHONDRIA
• *BREAST CANCER
• DEATH
• CELLS(BIOLOGY)
• BLOOD PROTEINS
• CHEMOTHERAPEUTIC AGENTS
• CYTOCHROME OXIDASE
• CYTOPLASM
• DIES
• PEPTIDE HYDROLASES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE