Accession Number:

ADA516613

Title:

Miniature and Molecularly Specific Optical Screening Technologies for Breast Cancer

Descriptive Note:

Annual rept. 1 Sep 2008-31 Aug 2009

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

• Ramanujam, Nimmi

Report Date:

2009-10-01

Pagination or Media Count:

19.0

Abstract:

The goal of this proposal is to harness the power of light to create miniature and molecularly specific optical technologies for breast cancer diagnosis and detection. The miniature technologies will leverage on millimeter scale silicon detectors and LEDs to make compact devices that can be used in a practical clinical setting for breast cancer detection. The features that will be exploited for optical detectiondiagnosis of breast cancer will include the physiological, structural and molecular alterations that accompany the transformation of a cell from a normal to malignant state. This proposal also focuses on using contrast agents, specifically aminolevulinic acid ALA induced protoporphyrin IX PpIX and NBDG, for the molecular detection of breast cancer.

Descriptors:

• *BREAST CANCER
• *OPTICAL DETECTION
• *OPTICAL INSTRUMENTS
• *DIAGNOSIS(MEDICINE)
• LIGHT EMITTING DIODES
• CONTRAST MEDIA(MEDICINE)
• LEVULINIC ACIDS
• CANCER SCREENING
• CELLS(BIOLOGY)
• SPECTROSCOPY
• FIBER OPTICS
• MINIATURIZATION

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE