DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE
to register or log in.
Comprehensive and Alternative Medicine in Preventing Radiotherapy-Induced Adverse Skin Reactions
Annual rept. 1 Aug 2008-31 Jul 2009
MIAMI UNIV FL
Pagination or Media Count:
In response to radiation therapy RT, many breast cancer patients experience early adverse skin reactions EASRs due to inflammation. Therefore, we test alternative medicine with anti-inflammatory properties, Calendula officinalis and Ching Wan Hung, in RT-induced EASRs. We have tested two animal models with two ionizing radiation IR sources. First, C57BL6 mice were used and IR was performed in a clinical facility Varian 2100C Linear Accelerator. Visible signs of radiation dermatitis, such as blood vessel dilation, erythema, scales, moist desquamation, were observed from day 8 to 20 with a peak on day 16. The mice treated with Calendula Officinalis shown a faster recovery compared to those treated with Ching Wan Hung. Due to new clinical regulation, we had to change IR source. Second, SKH-hr1 hairless mice were used and IR was performed in a research facility a 100 KV X-ray machine. No significant skin lesions or signs of radiation dermatitis were observed in all groups of animals. Mild skin reactions, such as reddening and scales, were observed in medicine-treated group around days 814. In summary, appropriate radiation dosage and topical medicine control will need to be evaluated in future studies as proposed in our no-cost-extension period.
APPROVED FOR PUBLIC RELEASE