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Imaging of Ep-CAM Positive Metastatic Cancer in the Lymph System
Annual rept. 15 Aug 2008-29 Dec 2009
BAYLOR COLL OF MEDICINE HOUSTON TX
Pagination or Media Count:
The majority of cancer mortalities occur not from the primary tumor but rather from distant metastases. Since the lymph system provides a route for the spread of metastatic cancer cells, it is not surprising that lymph node status serves as the primary prognostic indicator in most cancers. This work aims to improve the methodology for and accuracy of diagnosing cancer positive lymph nodes. Better diagnoses could increase survival by detecting more true positive nodes which can then be removed while reducing adverse affects by correctly identifying the negative nodes which can be retained and should contribute to improved overall lymph function. To date, metastatic tumors have been generated in the lymph nodes of mice and the IR800 labeled anti-Ep-CAM antibody injected intradermally to detect the tumors. To reduce possible complications associated with the large antibody molecule, we are developing a smaller, single chain binding fragment scFv against Ep-CAM.
APPROVED FOR PUBLIC RELEASE