Accession Number:

ADA516472

Title:

X-Ray Phase Imaging For Breast Cancer Detection

Descriptive Note:

Annual rept. 1 Sep 2008-31 Aug 2009

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

• Wu, Xizeng

Report Date:

2009-09-01

Pagination or Media Count:

26.0

Abstract:

The long term objective of the project is to develop a low-dose and quantitative phase x-ray imaging technique for facilitating breast cancer detection. Phase retrieval from a single phase contrast image is the key strategy for this project. In this period we have accomplished following tasks 1 Successfully developed a new phase retrieval method with a full account of the nonlinear Fresnel propagators. This new phase retrieval method provides the scientific foundation and framework for developing new and more accurate phase retrieval algorithms for this project. 2 Conducted the system design study for the project. Importantly we have determined the optimal imaging geometry based on the quantitative phase contrast visibility analysis. 3 Conducted system hardware integration. A prototype is developed and the tests showed that the prototype is well functioning for phase contrast image acquisition. In the coming year we will conduct phase imaging experiments with custom-made breast phantoms. Especially we will incorporate the measured source incoherence effects and CR-detector response effects into the phase retrieval algorithms for accurately reconstruction of the maps of projected electron densities of the phantoms.

Descriptors:

• *BREAST CANCER
• *DETECTION
• *ALGORITHMS
• OPTIMIZATION
• ELECTRON DENSITY
• REFRACTIVE INDEX
• X RAYS
• PHASE
• INCOHERENCE
• INTEGRATION
• COEFFICIENTS
• MAMMARY GLANDS
• TISSUES(BIOLOGY)
• CONTRAST
• MAMMOGRAPHY
• RADIATION

Subject Categories:

• Medicine and Medical Research
• Numerical Mathematics
• Electricity and Magnetism
• Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE