Superimposed Code Theoretic Analysis of Deoxyribonucleic Acid (DNA) Codes and DNA Computing
Final technical rept. Apr 2007-Sep 2009
MACULA (ANTHONY J) GENESSEO NY
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In this project, a synthetic Deoxyribonucleic Acid, DNA-based memory called ComDMems Combinatorial DNA Memories was developed. This research focused on the application and implementation of combinatorial based information theory and group testing to create associative DNA memories and to retrieve information stored in these DNA memories by chemical and electro-chemical means. This research demonstrates that this combinatorial method can feasibly yield billions of covert and synthetic DNA memory strands that carry object and process information. A key component of this innovation is the combinatorial method of bio-memory design and detection that encodes item or process information as numerical sequences represented in DNA. This DNA data structure can be read by the wet laboratory method polymerase chain reaction PCR and then algorithmically decoded to retrieve virtually an unlimited amount of item or process information that has been stored in the combinatorial memories. ComDMem is a content addressable memory CAM as opposed to a standard random access memory RAM. A standard RAM goes directly to a physical address and returns the contents. ComDMem achieves CAM when multiple parallel PCR probes, specific for certain pieces of information, search the ComDMem for memories that contain these pieces of information. In this way all memories associated with a concepts can be retrieved and decoded in parallel.
- Genetic Engineering and Molecular Biology
- Computer Hardware