Anthrax, Toxins and Vaccines: A 125-Year Journey Targeting Bacillus anthracis
CENTRE DE RECHERCHES DU SERVICE DE SANTE DES ARMEES LA TRONCHE (FRANCE)
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Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections and a yearly boost. many experts agree that it is now time for the next generation of human vaccines against anthrax. Accordingly, this review will succinctly focus upon pathogenesis of B. anthracis, with particular emphasis upon the immune system the pertinent biophysical nature of protective antigen, which includes how the protein toxin component affords protection as a vaccine target alternative methods for improving protective antigen as an immunogen and additional B. anthracis antigens that might further sustain protective titers in humans. In addition to a better understanding of the disease process elicited by B. anthracis, which will logically lead to better vaccines and therapeutics, there also needs to be the same level of open-mindedness applied to the politics of anthrax.
- Medicine and Medical Research