Mechanism of Selenium Chemoprevention and Therapy in Prostate Cancer
Annual rept. 26 Sep 2008-30 Oct 2009
CALIFORNIA UNIV DAVIS
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Prevention trials demonstrated that selenium is a promising chemopreventive agent for prostate cancer. Selenium inhibited human prostate cancer cell growth, blocked cell cycle progression, and induced apoptotic cell death. We have demonstrated a novel mechanism of selenium anticancer action in which selenium markedly reduces androgen receptor AR expression and AR-mediated gene expression including prostate-specific antigen PSA in human prostate cancer cells in vitro and in vivo. Based on our novel finding that selenium disrupts AR signaling by reducing AR expression, it is conceivable that selenium reducing AR expression might improve the efficacy of androgen deprivation therapy. In this application, we will test the effects of selenium on prostate cancer therapy.
- Medicine and Medical Research