Department of Defense Era of Hope Scholar Award "Nanotechnology-Enabled Optical Molecular Imaging of Breast Cancer"
Annual rept. 15 Jun 2008-14 Jun 2009
RICE UNIV HOUSTON TX
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This project focuses on development of nanotechnology-enabled optical molecular imaging technologies for applications in both breast cancer diagnosis and monitoring therapeutic response. The project consists of two major efforts 1 optical instrumentation technology development and 2 development of complementary engineered nanomaterials for use in conjunction with the instrumentation created to provide molecular specificity. A particularly significant effort is underway to develop needle-compatible fiber optic probes to enable in vivo imaging of tumors with micron resolution in order to provide a new microscopic, high resolution imaging modality to complement the low resolution, macroscopic imaging modalities already in common clinical use. Over the first two years of this effort, a first and second generation needle-compatible fiber optic probe system have been developed as have new methods for synthesis and bioconjugation of shaped and layered gold nanoparticle imaging agents and cadmium-free luminescent quantum dots.
- Medicine and Medical Research